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eComment: Re: Is repeated administration of blood-cardioplegia really necessary?

Bakoulev Center for Cardiovascular Surgery, 121552 Moscow, Russia

Is repeated administration of blood-cardioplegia really necessary?

The problem of intraoperative myocardial protection using intermittent warm blood cardioplegia still gives rise to more questions than answers. There are no standard adopted protocol for cardioplegia administration, no protocol confirming the safety of various time periods between reinfusion runs, and no data on myocardium metabolism during warm cardioplegic ischemia. This work demonstrates the possibility to prolong singleshot cardioplegic ischemia up to 40 min [1]. The results confirm data previously obtained by several authors. However, we still have no substantiated protocol and no clear determination of the duration of safe normothermic cardioplegic ischemia. We are not aware of the process of myocardial metabolism disturbances which can be reversible, but probably can affect unfavourably the postoperative course. Prompt performance of surgical intervention cannot be judged as an index of satisfactory intraoperative myocardial protection, especially if the period of cardioplegic ischemia does not exceed 60 min. The conclusions presented in the article seem logical, but they need to be backed up by an in-depth study of the state of myocardium using different markers of this injury.

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1. Ghazy T, Allham O, Ouda A, Kappert U, Matschke K. Is repeated administration of blood-cardioplegia really necessary? Interact CardioVasc Thorac Surg 2009;8:517–523.[Abstract/Free Full Text]

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Leo A. Bockeria Permission Requests Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Bockeria, L. A. Search for Related Content PubMed PubMed Citation Articles by Bockeria, L. A. Related Collections Related Article