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Interact CardioVasc Thorac Surg 2008;7:749. doi:10.1510/icvts.2008.181057A
© 2008 European Association of Cardio-Thoracic Surgery
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eComment: Myocardial protection: efficacy of a novel magnesium-basedcardioplegia (RS-C) compared to St Thomas' Hospital cardioplegic solution

Leo A. Bockeria, Ruben R. Movsesyan, Dmitriy V. Ryabtsev and Tigran R. Grigoryants

Bakoulev Center for Cardiovascular Surgery, 121552 Moscow, Russia

Myocardial protection: efficacy of a novel magnesium-based cardioplegia (RS-C) compared to St Thomas' Hospital cardioplegic solution

In spite of the fact that St. Thomas' Hospital solution is commonly used, there are some well known disadvantages. First of all, the slight buffer base makes difficulties during a prolonged ischaemia. But the new buffered solution might improve cardiac protection [1]. In relation to the electrolytic part we need to be more exact. Potassium is absent in the described solution so histiocytes that accumulate calcium, can be damaged [2]. Calcium can not leave a cell because magnesium blocks the cells penetrability. At present a low-calcium solution (Custodiol HTK solution) is used for calcium elimination, but the described solution is maladapted for it. We conclude that the new non-potassium solution still requires long-term experimental and clinical research.


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  1. Maruyama Y, Chambers DJ. Myocardial protection: efficacy of a novel magnesium-based cardioplegia (RS-C) compared to St Thomas' Hospital cardioplegic solution. Interact CardioVasc Thorac Surg 2008;7:745–749.[Abstract/Free Full Text]
  2. Ledingham SJ, Braimbridge MV, Hearse DJ. Improved myocardial protection by oxygenation of St. Thomas' Hospital cardioplegic solutions. Studies in the rat. J Thorac Cardiovasc Surg 1988;95:103–111.[Abstract]

Related Article

Myocardial protection: efficacy of a novel magnesium-based cardioplegia (RS-C) compared to St Thomas' Hospital cardioplegic solution
Yuji Maruyama and David J. Chambers
Interactive CardioVascular and Thoracic Surgery 2008 7: 745-749. [Abstract] [Full Text] [PDF]




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