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ICVTS on-line discussion A

Hospital de Cruces, Barakaldo 48903, Spain; Hospital Clinic, Barcelona, Spain

Is short-term anticoagulation necessary after mitral valve repair?

eComment: The authors deal with a very interesting topic of oral anticoagulation after mitral valve repair [1]. Although most of us would agree to use warfarin in patients in atrial fibrillation, the most frequent type of repair is quadrangular resection of P2 due to fibroelastic deficiency. Most of these patients are relatively young and in normal sinus rhythm. Is it justified to give warfarin to these patients? Present indication to do so is based on consensus and only by the European Society of Cardiology. Up to 40% of surgeons do not use anticoagulation in this low-risk population. There are no randomized controlled trials to support the safety of omitting warfarin in this setting, but there are no such trials to support the need for oral anticoagulation either. We studied 31 mitral repair patients treated with ticlopidine or warfarin and found a statistically significant difference in prevention of thromboembolism favoring ticlopidine [2]. The study had some limitations, mainly the absence of randomization, but served as a pilot study in this topic. We reported the first randomized controlled trial [3] on the use of antiplatelet treatment after aortic tissue valve replacement in 2005. Antiplatelet treatment was as useful as warfarin in preventing thromboembolism but proved to be safer reducing the rate of bleeding problems. In the ACC/AHA guidelines published this year [4], aspirin is the treatment of choice in aortic bioprosthesis with no risk factors, class I, being the use of oral anticoagulation a second choice, class IIa. With the present refinements in surgical technique and medical therapy, patients having a quadrangular resection of P2 or equivalent mitral repair with no associated risk factors could benefit from the same treatment approach as aortic bioprosthesis. Therefore, we believe that there is a place for controlled trials on this topic in the near future, so that we can satisfy the need for evidence of those surgeons who are using alternatives to oral anticoagulation.

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1. Asopa S, Patel A, Dunning J. Is short term anticoagulation necessary after mitral valve repair? Interact CardioVasc Thorac Surg 2006; 5:761–766.[Abstract/Free Full Text]
2. Aramendi JL, Agredo J, Llorente A, Larrarte C, Pijoan J. Prevention of thromboembolism with ticlopidine shortly after valve repair or replacement with a bioprosthesis. J Heart Valve Dis 1998; 7:610–614.[Medline]
3. Aramendi JI, Mestres CA, Martinez-Leon J, Campos V, Munoz G, Navas C. Triflusal versus oral anticoagulation for primary prevention of thromboembolism after bioprosthetic valve replacement (trac): prospective, randomized, co-operative trial. Eur J Cardiothorac Surg 2005; 27:854–880.[Abstract/Free Full Text]
4. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. Circulation 2006; 114:e84–231.[Free Full Text]

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