Lidocaine-magnesium blood cardioplegia was equivalent to
potassium blood cardioplegia in left ventricular
function of canine heart
Shohjiro Yamaguchi 1*,
Go Watanabe 1,
Shigeyuki Tomita 1,
Shigeki Tabata 1
1 University of Kanazawa, Japan
* To whom correspondence should be addressed. E-mail: gucci-s{at}ya2.so-net.ne.jp.
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Abstract |
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This study evaluated the effects of lidocaine-magnesium blood cardioplegia on left ventricular function compared with potassium blood cardioplegia. Crystalloid cardioplegia which contains lidocaine has been reported but blood cardioplegia is rare. Thirteen dogs received 60 min of global ischemia under hypothermic cardioplumnary bypass (30 °C). Potassium blood cardioplegia was administered every 20 min in group A (n=6), and lidocaine-magnesium blood cardioplegia in group B (n=7). We compared the ratio of Emax obtained during IVC occlusion at pre- and post-global ischemia (%Emax) and LVSW (%LVSV). Cardiac function was evaluated prior to CPB and 60 min after reperfusion. There was no difference in time required for cardiac arrest between the two groups (group A: 78±3 s, group B: 89±9 s). % Maximal elastance was significantly better in group B (group A: 63±3%, group B: 76±4%, p<0.05). % Tissue water content of the myocardium after CPB was significantly lower in group B (group A: 82.3±4%, group B: 75.5±2%, p<0.05). Lidocaine-magnesium blood cardioplegia was equivalent to potassium blood cardioplegia in systolic left ventricular function and reduced myocardial edema in canine heart. Keywords: Cardioplegia; Lidocaine; Myocardial protection; Polarized arrest
