Warm induction cardioplegia and reperfusion dose
influence the occurrence of the post CABG TnI level
Bingyang Ji 1*,
Mingzheng Liu 2,
Feng Lu 2,
Jinping Liu 2,
Guyan Wang 2,
Zhengyi Feng 2,
Qiang Hu 2
1 Hershey Medical Center, PA, USA
2 Fuwai Hospital, Beijing, China
* To whom correspondence should be addressed. E-mail: bingyangji{at}psu.edu.
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Abstract |
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As a new biochemical marker cardiac troponin-I (CTnI) is more sensitive and specific marker for detection of differences in myocardium injuries than other chemical enzymes. This study investigates the effect of warm induced and reperfusion blood cardioplegia on the release of troponin-I during the CABG. In our research 24 three-vessel coronary artery disease (CAD) patients underwent CABG were divided into two groups randomly: Group of warm induction and reperfusion blood cardioplegia (Group W N=12); Group of simple warm induction and no reperfusion (Group C N=12). The effect of myocardium protection of the two method of myocardium protection were evaluated by clinical outcome, CTnI. Serial venous blood samples were obtained before and after surgery. In both two groups, there were no differences in operative parameters. The level of CTnI increased from postoperative 6 h (p<0.05), reached peak in 24~72 h and recovered postoperative 6th day in both groups. Compared with group C, the plasma concentration of CTnI in group W were significantly lower at 6 h, 24 h and 72 h (p<0.01). The results suggest that the method of warm induction and reperfusion blood cardioplegia reduce the leakage of CTnI than group of simple warm blood cardioplegia in CABG patients. Keywords: Myocardial protection; Troponin-I; Cardioplegia; Cardiopulmonary bypass
