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Thymic neuroblastoma with the syndrome of inappropriate secretion of antidiuretic hormone

Department of Thoracic Surgery, Kitasato University School of Medicine, 1-15-1, Kitasato, Sagamihara, Kanagawa 228-8555, Japan

*Corresponding author. Tel.: +81-427-788111; fax: +81-427-789840.

E-mail address: ysatoh{at}med.kitasato-u.ac.jp (Y. Satoh).

We describe a rare case of thymic neuroblastoma with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). A 60-year-old male patient was admitted to our hospital for further examination and treatment of anterior mediastinal tumor found at a regular health check-up. On examination there was hyponatremia, decrease in plasma osmolarity and elevation of plasma antidiuretic hormone (ADH) level. Thus, he underwent total thymectomy under the diagnosis of thymoma with SIADH. The tumor was located in the right lobe of the thymus and the final diagnosis was thymic neuroblastoma. To our knowledge, this is the first reported case of thymic neuroblastoma in which production of ADH by tumor cells is demonstrated immunohistochemically. This case highlights the need to consider functional activity of thymic neuroblastoma and complete resection of the tumor is warranted for treatment.

Key Words: Anterior mediastinal tumor; Neuroblastoma; Syndrome of inappropriate secretion of antidiuretic hormone