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Postoperative administration of landiolol hydrochloride for patients with supraventricular arrhythmia: the efficacy of sustained intravenous infusion at a low dose

^a Department of Surgery II, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan
^b Intensive Care Unit, Kochi University Hospital, Kochi, Japan
^c Emergency Medicine, Kochi University Hospital, Kochi, Japan

*Corresponding author. Tel.: +81-88-880-2375; fax: +81-88-880-2376.

E-mail address: wari{at}kochi-u.ac.jp (S. Wariishi).

The purpose of this study was to investigate the efficacy of landiolol hydrochloride, a short-acting β₁ blocker, by initiating its administration at a low dose (5 µg·kg^–1·min^–1) in patients with postoperative supraventricular arrhythmia. The efficacy of landiolol was evaluated in 38 patients who, after developing postoperative atrial flutter or fibrillation, with sinus tachycardia and two patients who had a history of paroxysmal atrial fibrillation with frequent atrial extrasystole. The heart rate and blood pressure before and 2 h after the administration of landiolol were compared. A return to the sinus rhythm from supraventricular arrhythmia was noted in 89%. The heart rate was reduced from 137±26 bpm (before landiolol administration) to 93±18 bpm (2 h after the start of the medication, P<0.01). As an agent to correct an arrhythmic condition, landiolol successfully raised the systolic blood pressure from 108±24 mmHg (before medication) to 120±19 mmHg (2 h after the medication was started, P<0.05). Continuous intravenous infusion of landiolol at a low dose was found to be effective for postoperative supraventricular arrhythmia.

Key Words: β blocker; Landiolol hydrochloride; Postoperative care; Supraventricular arrhythmia