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Chromosomal deletion in patients with malignant pleural mesothelioma

^a St Vincent's Medical Center, Department of Surgery, New York Medical College, School of Medicine, 130 West 12th Street, New York City, NY 10011, USA
^b Division of Thoracic Surgery, Department of Surgery, Harvard Medical School, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA

*Corresponding author. Tel.: +1 617 9352782.

E-mail address: Sneragi{at}yahoo.com (S. Neragi-Miandoab).

Malignant pleural mesothelioma (MPM) is associated with frequent deletions of specific chromosomal regions within 1p, 3p, 6q, 9p, 13q, 15q, and 22q. In this retrospective review of our patients with MPM, the tumor tissue of 40 patients (31 male and 9 female) was evaluated for chromosomal deletions and was karyotyped. Chromosomal deletions in regions 1p, 3p, 6p, 9p, 6q, 9q, 22q were observed in 22 of 40 patients (55%). Of this group of 22 patients, 15 (68%) demonstrated deletions in chromosome 6; 12 (54%) exhibited deletions in chromosome 22q; and 13 (59%) had deletions in chromosome 9p. Asbestos exposure was found in only 13 of the 22 patients (59%) with chromosomal deletions. There was no correlation between asbestos exposure and chromosomal deletion (95% CI –0.38–0.23, P=0.63). Chromosomal deletion did not correlate with age (95% CI –0.45–0.14, P=0.29). The majority of patients with chromosomal deletions had epithelial histology (17 of 22 patients; 77%), which was not statistically significant (95% CI –0.14–0.46, P=0.27). Chromosomal deletion is common in tumor tissue of MPM and the inactivation of tumor suppressor genes (TSGs) residing in these chromosomes may contribute to mesothelial cell tumorigenesis.

Key Words: Genetic analysis; Malignant transformation; Genetic susceptibility; Malignant pleural mesothelioma