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Apolipoprotein E alleles and bicuspid aortic valve stenosis in monozygotic twins

Department of Cardiology, University Hospital of South Manchester, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK

*Corresponding author. Tel.: +44 161 2751208, +44 7886 348056; fax: +44 161 2751183.

E-mail address: palaniappan.saravanan{at}manchester.ac.uk (P. Saravanan).

Aortic valve disease is a common valvular heart disease but the underlying pathology that leads to the severe dysfunction of the aortic valve is unclear. There is increasing interest in the role of hypercholesterolaemia in the causation and progression of aortic valve disease. Apolipoprotein E is an essential component of cholesterol and previous studies have reported conflicting results on the association between various apolipoprotein E alleles and aortic valve disease. We report two interesting cases of severe dysfunction of bicuspid aortic valves in twin brothers who presented to us at the same time.

Key Words: Bicuspid aortic valve; Aortic stenosis; Apolipoprotein E alleles