This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Eric Bezon Jean Auber Barra Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bezon, E. Articles by Barra, J. A. Search for Related Content PubMed PubMed Citation Articles by Bezon, E. Articles by Barra, J. A.

Use of arterial patch to improve re-endothelialization in a sheep model of open carotid endarterectomy. An incentive to use internal thoracic artery as an on-lay patch following coronary endarterecomy?

^a Department of Cardio-vascular and Thoracic Surgery, University Hospital La Cavale Blanche, Brest, France
^b Department of Medicine, University Hospital La Cavale Blanche, Brest, France
^c Department of Cardiology, University Hospital La Cavale Blanche, Brest, France

*Corresponding author. Service de chirurgie cardiaque, thoracique et vasculaire. C.H.U. La Cavale Blanche, 29609 Brest Cedex, France. Tel.: +(33) 2 98 34 74 28; fax: +(33) 2 98 34 78 10.

E-mail address: eric.bezon{at}chu-brest.fr (E. Bezon).

To better understand the effect of the internal thoracic artery on endothelial growth after open coronary endarterectomy, we designed an experimental test of the hypothesis that closing an endarterectomized artery by an arterial patch improves re-endothelialization. The two carotid arteries were endarterectomized in nine sheep and were randomly chosen for closure by native arterial femoral (ART) patch or polytetrafluoroethylene (PTFE) patch. Three animals were randomly chosen for sacrifice at 8, 15 and 21 days each. The endarterectomized segments were studied macroscopically and microscopically. The endarterectomized area covered with adhesive thrombus was more extensive in the PTFE than in the ART group (P=0.0117). In the ART group, the regenerated endothelium was normal and sprouted from the edges of both the endarterectomy and the arterial patch towards the central endarterectomized area. In the PTFE group, it sprouted from the edges of the endarterectomy and never reached the central endarterectomized area, where abnormal endothelium was observed. The endarterectomized area covered with normal endothelium was more extensive in the ART than in the PTFE group at 8 days, at 15 days, and 21 days (P<0.001). Arterial patch closure of open-endarterectomized artery improved regenerated endothelium quality.

Key Words: Endarterectomy; Animal model; Autograft; Endothelium

This article has been cited by other articles:

				D. Nezic, A. Knezevic, M. Cirkovic, and S. Micovic eComment: How to reconstruct endarterectomized left anterior descending coronary artery Interactive CardioVascular and Thoracic Surgery, October 1, 2009; 9(4): 738 - 738. [Full Text] [PDF]