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Carbon monoxide induces relaxation of human internal thoracic and radial arterial grafts

^a Department of Cardiothoracic and Vascular Surgery, European Hospital Georges Pompidou, 20 Rue Leblanc, 75015 Paris, France
^b Faculté de Mé decine Paris Descartes, Université René Descartes, Paris, France
^c Department of Angiology, Servier Research Institute, 11 Rue des Moulineaux, 92150, Suresnes, France

Corresponding author. Tel.: +33 713 922 2393; fax: +33 713 500 0647.

E-mail address: paulachouh{at}softhome.net (P.E. Achouh).

Carbon monoxide is produced by the degradation of heme by intracellular heme-oxygenase. The aim of our study was to evaluate, in vitro, the vasodilating effect of carbon monoxide and its mechanisms of action on human internal thoracic and radial artery grafts. Segments of human internal thoracic artery and radial artery, obtained from isolated coronary artery bypass surgery patients, were studied in organ chambers. The arterial rings were precontracted with norepinephrine then submitted to carbon monoxide. Inhibitors of nitric oxide synthase and of soluble guanylate cyclase were added to some arterial rings. Carbon monoxide induced significant relaxation in precontracted human internal thoracic artery and radial artery rings. This relaxation was independent of the presence of functional endothelium in internal thoracic artery. Blocking soluble guanylate cyclase partially inhibited this relaxation, while blocking nitric oxide synthase had no effect. Carbon monoxide has a relaxing effect on human internal thoracic artery and radial artery grafts in vitro, partially via cyclic guanylate monophosphate (cGMP) pathway activation. Inducing carbon monoxide production at the cellular level in vivo in human arterial grafts might help prevent vasospasm.

Key Words: CABG; Nitric oxide; Arterial grafts

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				U. Goebel and M. Siepe eComment: Carbon monoxide and its vasodilatative properties: another good reason for clinical implication Interactive CardioVascular and Thoracic Surgery, December 1, 2008; 7(6): 962 - 963. [Full Text] [PDF]