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Lung perfusion during cardiac surgery with cardiopulmonary bypass: is it necessary?^,

^a Division of Cardiovascular Surgery, Department of Surgery, Federal University of Sao Paulo, Rua Napoleao de Barros, 715, 3o andar, Vila Clementino 04023900, Sao Paulo, Brazil
^b Division of Gynecology and Molecular Biology, Federal University of Sao Paulo, Brazil
^c Division of Pathology, University of Sao Paulo, Brazil
^d Division of Cardiothoracic Surgery, Miller School of Medicine, Jackson Memorial Hospital, University of Miami, USA

Corresponding author. Rua Melo Alves, 685, apto 171 01417010 Cerqueira César, São Paulo, Brazil. Tel.: +(55) (11) 99863657; fax: +(55) (17) 32343787.

E-mail address: edag{at}uol.com.br (E.A. Gabriel).

Thirty-two pigs were randomized into group I (aortic cross clamping, antegrade cardioplegia, moderate hypothermia) and group II (normothermia, beating empty heart). Groups were subdivided into subgroups A, B and C, receiving no lung perfusion, perfusion with arterial blood and perfusion with venous blood. Swan-Ganz catheter was used to take mean pulmonary artery pressure which would be used as lung perfusion pressure. Cardiopulmonary bypass (CPB) was established through cannulating aorta and double venae cavae, mechanical ventilation was interrupted and lung perfusion was carried out for 30 min. Blood samples and pulmonary specimens were withdrawn pre- and postoperatively for gasometrical, histological and genic analyses. Postoperative comparison revealed that pulmonary vascular resistance was lower in IC than IA (P=0.01) and it was lower in IIC than IIA (P=0.005). Subgroup IIB had increasing venous oxygen tension (P=0.01) as well as arterial and venous oxygen saturation (P=0.01) compared to IIA. Arterial oxygen saturation was decreased in IIC vs. IIA (P=0.006). Histological differences were observed between subgroups A and B as well as A and C (P=0.003). Lung perfusion during CPB may improve pulmonary hemodynamic performance, optimize gas exchange and maintain cellular integrity.

Key Words: Lung; Perfusion; Cardiopulmonary bypass