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Adenovirus-mediated stromal cell-derived- factor-1 gene transfer induces cardiac preservation after infarction via angiogenesis of CD133⁺ stem cells and anti-apoptosis

^a Institute of Clinical Medicine, Renmin Hospital, Yunyang Medical College, Shiyan, Hubei 442000, People's Republic of China
^b Department of Physiology, Yunyang Medical College, Shiyan, Hubei 442000, People's Republic of China

*Corresponding authors. Tel.: +86-719/8637170; fax: +86-719/8637011.

E-mail address: tangjm416{at}163.com (J. Tang), rywjn{at}vip.163.com (J. Wang).

In our study, we found cardiocytes expressed CXCR4, and the number of cardiocytes apoptosis with SDF-1 treatment decreased obviously through SDF-1 induced the up-regulation of phosphorylated Akt. On day 7 after myocardial infarction, marked expression of SDF-1, and the number of CD133⁺ cells was the highest in the AdV-SDF-1 injection hearts. On day 28 post-treatment, blood vessel density in the AdV. SDF-1 group was higher in infracted zones. Infarct size and collagen accumulation in the infracted area decreased significantly, thickness of LV wall, vessels and cardiocytes' density increased obviously in the AdV-SDF-1 group than in control or Adv-LacZ group, and hemodynamics showed the improvement of left ventricle heart function in the AdV.SDF-1 group. Therefore, SDF-1 could improve cardiac structure and function through the combined effects of angiogenesis and anti-apoptosis.

Key Words: Myocardial infarction; SDF-1; Stem cell; Angiogenesis; Apoptosis