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Transfusion practice in coronary artery bypass surgery in Denmark: a multicenter audit^,

^a Department of Cardiothoracic Surgery, Aalborg Hospital, Aarhus University Hospital, Hobrovej, Postboks 365, DK-9100 Aalborg, Denmark
^b Department of Cardiothoracic Surgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
^c Department of Cardiothoracic Surgery, Odense University Hospital, Odense, Denmark
^d Department of Cardiothoracic Surgery, Gentofte Hospital, University of Copenhagen Hellerup, Denmark
^e Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Denmark
^f Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark

*Corresponding author. Tel.: +45 99322964; fax: +45 99322425.

E-mail address: jan.jesper.andreasen{at}stofanet.dk (J.J. Andreasen).

Transfusion rates in coronary artery bypass grafting (CABG) continue to vary substantially, although guidelines for allogeneic transfusion have been developed. In order to evaluate ongoing transfusion practices, we performed a multicenter audit in four Danish hospitals regarding the use of allogeneic blood products among patients undergoing first-time CABG. Data on patient characteristics, peri- and postoperative factors were retrieved from 600 patient records (150 records per hospital). Substantial differences were seen regarding preoperative intake of antiplatelet drugs, perioperative use of antifibrinolytic drugs, use of cardiopulmonary bypass (CPB), cross-clamp time, time on CPB, lowest hemoglobin during CPB, and number of distal anastomoses. The percentage of patients transfused with allogeneic red blood cells ranged from 30.0% to 64.2%. Several patients (12.1–42.7%) transfused with red blood cells were discharged with a hemoglobin concentration >7 mmol/l, indicating inappropriate transfusions. The relative risk of receiving an allogeneic blood transfusion was 2.1 (95% CI: 1.6–2.7) in the hospital with the highest transfusion rate, after adjustment for patient-, drug-, and procedure-related factors. Interesting differences in transfusion rates exists in Danish hospitals and these differences may reflect true variations in transfusion practices. Audits create a basis for educational efforts among surgeons and anesthesiologists to standardize transfusion practices.

Key Words: Transfusion; Coronary artery bypass grafting; Blood loss