This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Buchs, J.-B. Articles by Morel, P. Search for Related Content PubMed PubMed Citation Articles by Buchs, J.-B. Articles by Morel, P. Related Collections Extracorporeal circulation Transplantation - heart

A new disposable perfusion machine, nuclear magnetic resonance compatible, to test the marginal organs and the kidneys from non-heart-beating donors before transplantation

Service de Chirurgie Viscérale et de Transplantation, HUG, 1211 Genève, Switzerland

*Corresponding author. HUG – 24 rue Micheli-du-Crest, 1205 Genève, Switzerland.

E-mail address: jean-bernard.buchs{at}hcuge.ch (J.-B. Buchs).

This article is the first report about our new hypothermic pulsatile perfusion machine (HUG's HPP-machine) for kidney perfusion. This machine will be used for ³¹P NMR spectroscopy. The aim is to obtain scores of viability of marginal kidneys and those from non-heart-beating donors (NHBD) before transplantation using HPP as it has been demonstrated necessary in these situations. The most predictable test is the ratio of phosphomonoester on inorganic phosphorus (PME/Pi) that can be obtained from ³¹P spectroscopy. The machine has been built to allow perfusion of kidneys in the range of that performed with the traditional Belzer, Mox-Waters machines and others, but compatible with the magnetic fields of the MRI apparatus used for ³¹P NMR spectroscopy. In this publication, the technical aspects of this new aerobic HPP-machine compatible with MRI is presented.

Key Words: Hypothermic pulsatile perfusion; ³¹P NMR; Non-heart-beating donor (NHBD); MRI compatibility