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Visceral pleural infiltration as a negative prognostic factor in lung metastasis

^a Department of Surgery, University of Szeged, Pécsi u. 4. H-6720, Szeged, Hungary
^b Department of Pathology, University of Szeged, Állomás u. 2. H-6725, Szeged, Hungary
^c Department of Medical Informatics, University of Szeged, Korányi fasor 9. H-6720, Szeged, Hungary

*Corresponding author. Tel.: +36-30-9955815; fax: +36-62-545 701.

E-mail address: jfurak{at}hotmail.com (J. Furák).

The prognostic value of visceral pleural infiltration in lung metastasis was analysed. Fifty-two patients (32 males and 20 females) were operated on for lung metastases. The locations of the primary tumours were as follows: 19 colon, 10 kidneys, 8 melanomas, 3 breast, 3 bladder, 2 uterus, 2 osteosarcomas, 1 testis, and 1 parotid, 1 haemangiopericytoma, 1 thyroid gland and 1 larynx. Explorative thoracotomies and incomplete resections were excluded from the study. Visceral pleural infiltration was present in 20 of the 52 cases. There was a significant correlation between the occurrence of pleural infiltration and multiple lesions (P=0.019). The overall five-year survival rate was 33.6%. In a subgroup of 38 patients with N0 and single metastases, the five-year survival rate was 73% and 12% in the cases without and with visceral pleural infiltration, respectively (P=0.003). Multivariate analysis of pleural infiltration, lymph node metastasis, multiple lesions and DFI revealed that only pleural infiltration (P=0.003) had a significant impact on survival. In one-third of the pulmonary metastases, visceral pleural infiltration appeared. There was a significant correlation between the occurrence of visceral pleural infiltration and multiple lesions. Visceral pleural infiltration in lung metastasis is a negative prognostic factor, and in these cases, survival was significantly reduced.

Key Words: Pulmonary metastasis; Visceral pleural infiltration; Prognostic factor