This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Martin Hartrumpf Johannes M. Albes Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Just, S. S. Articles by Albes, J. M. Search for Related Content PubMed PubMed Citation Articles by Just, S. S. Articles by Albes, J. M. Related Collections Extracorporeal circulation

First experience with closed circuit/centrifugal pump extracorporeal circulation: cellular trauma, coagulatory, and inflammatory response

Department of Cardiothoracic Surgery, Heart-Center Brandenburg, Bernau, Germany

*Corresponding author. Heart-Center Brandenburg, Ladeburger Str. 17, 16321 Bernau, Germany. Tel.: +49(0)3338 694123/694510; fax: +49(0)3338 694544.

E-mail address: s.just{at}immanuel.de (S.S. Just).

Closed circuit extracorporeal circulation comprising a centrifugal pump has been developed to reduce deleterious effects of standard cardiopulmonary bypass. This study compares such a system with standard extracorporeal circulation (ECC). Twenty patients underwent isolated routine coronary artery revascularization. Ten patients underwent ECC. Ten patients were operated upon using a closed circuit/centrifugal pump system with coated surfaces (ISS) (SYNERGY, Stöckert). Both groups did not differ regarding age, body mass, left ventricular function, number of bypasses, and concomitant diseases. Free hemoglobin (fHb), plasmin–antiplasmin complex (PAPc), platelet function (ROTEG), and interleukin 6 (IL-6) were measured preoperatively, intraoperatively (after sternotomy, during X-Clamp, during reperfusion, post ECC or ISS), and postoperatively. Technical problems were not observed. The ISS group demonstrated significantly less fHb during bypass, a lower intraoperative myocardial damage as well as less increase in IL-6 after bypass and postoperatively compared to ECC. In ISS fluid balance was significantly lower than in ECC whereas drainage loss and hospitalization did not differ statistically. Extracorporeal circulation with a closed circuit/centrifugal pump system can be routinely employed and appears to be safe. Intraoperative and early postoperative reduction of red blood cell trauma and inflammation are of potential value.

Key Words: Minimally invasive cardiopulmonary bypass

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				S. S. Just, T. Muller, and J. M. Albes Minimized closed circuit/centrifugal pump extracorporeal circulation: an effective aid in coronary bypass operations in Jehovah's Witnesses Interactive CardioVascular and Thoracic Surgery, February 1, 2007; 6(1): 124 - 125. [Abstract] [Full Text] [PDF]