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Prognostic significance of cyclin D1 expression in resected stage I, II non-small cell lung cancer in Arabs

^a Department of Surgery, Faculty of Medicine, Kuwait University, Chest Diseases Hospital, P.O. Box 24923, Safat 13110, Kuwait
^b Department of Pathology, Kuwait Cancer Center, Ministry of Health, Kuwait

*Corresponding author. Tel.: (965) 5319475; fax: (965) 5319579.

E-mail address: Adel{at}hsc.edu.kw (A.K. Ayed).

The aim of this study was to evaluate the prognostic significance of cyclin D1 expression in primary, resected stage I and II non-small cell lung cancer (NSCLC) in Arabs. A longitudinal cohort study of 98 consecutive patients with resected stage I and II NSCLC were evaluated immunohistochemically for the expression of cyclin D1 and determined its prognostic significance by comparison with follow-up data from January 1994 to December 1999. This study included 76 male and 22 female patients. They represented 31 stage I NSCLC and 67 stage II tumors. Expression of cyclin D1 was detected immunohistochemically in 48 (49%) of the 98 NSCLC. Cyclin D1 expression had significantly higher positive results in patients with chronic obstructive pulmonary disease (P=0.001), poorly differentiated carcinoma (P=0.001), presence of vascular invasion (P=0.003), and visceral pleural invasion (P=0.005). Patients with cyclin D1-positive tumors had shorter survival than those with cyclin D1-negative tumors (5-year survival rates, 48% and 74%, respectively; P=0.006 by the log-rank test). In conclusion, a higher percentage of NSCLC with visceral pleural invasion, vascular invasion, poor differentiation of the tumor, patients with chronic obstructive pulmonary disease have positive cyclin D1 expression than other lung tumors.

Key Words: Cyclin D1 expression; Non-small cell lung cancer; Prognostic factor