ICVTS Click here to goto Smart Canula website
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Xia, Z.
Right arrow Articles by Liu, X.-Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xia, Z.
Right arrow Articles by Liu, X.-Y.
Related Collections
Right arrow Cardiac - pharmacology
Right arrow Myocardial protection
Interactive Cardiovascular and Thoracic Surgery 3:528-532(2004)
© 2004 European Association of Cardio-Thoracic Surgery

Institutional report - Cardiac general

Systemic ischemic preconditioning plus hemodilution enhanced early functional recovery of reperfused heart in the rabbits

Zhengyuan Xiaa,*,1, Rui Xiaa,2, Hai-Tao Lanb, Tao Luoa, Qi-Zhu Tangc, Zhong-Yuan Xiaa and Xian-Yi Liua

a Department of Anesthesiology, Renmin Hospital, Wuhan University, Wuhan 430060, China
b Department of Anesthesia, Guangdong Provincial Corps Hospital, Chinese Armed Polices, Guangzhou 510507, Wuhan,China
c Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, China

* Corresponding author. Tel.: +1-604-822-6980; fax: +1-604-822-6012
zhengyuan_xia{at}yahoo.com

We investigated whether transient systemic ischemia can precondition the heart against the ensuing ischemic insult. Rabbits were randomly divided into systemic ischemic preconditioning (SIP), hemodilution (HD) and control (C) groups. SIP was induced by rapidly withdrawing blood from femoral artery and maintaining the mean artery pressure at 50 mmHg for 10 min. Afterwards, 50% of the withdrawn blood was re-infused with equal volumes of 6% deferoxamine-conjugated hydroxyethyl-starch (D-HES). Hemodilution in HD group was achieved by withdrawing blood at 8 ml/kg accompanied by concomitant infusion of equal volumes of D-HES. Animals were subjected to 30 min of coronary artery occlusion followed by 120 min of reperfusion. Cardiac output (CO) (thermodilution method), plasma malondialdehyde and nitric oxide content were measured at baseline and until 120 min of reperfusion. At CO in group-C was significantly lower than its baseline value, accompanied by a significant reduction in nitric oxide production and increase in malondialdehyde concentration; CO in group-SIP and group-HD maintained at baseline levels throughout reperfusion. At CO in group-SIP, but not in group-HD, was significantly higher than that in group-C. It is concluded that transient SIP followed by hemodilution with D-HES facilitates early functional recovery of the ischemic-reperfused rabbit hearts.

Key Words: Systemic ischemic preconditioning; Myocardial ischemia; Rabbits; Hemodilution; Reperfusion

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2004 European Association for Cardio-thoracic Surgery