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Untreated tetralogy of Fallot in an adult patient complicated by acute aortic valve endocarditis

Division of Thoracic and Cardiovascular Surgery, Hanover Medical School, Carl Neuberg Str. 1, 30625 Hanover, Germany

^* Corresponding author. Tel.: +49-532-6581; fax: +49-532-5404
knobloch{at}thg.mh-hannover.de

Acute endocarditis complicated by aortic valve regurgitation is an uncommon finding in adults with surgical untreated tetralogy of Fallot (TOF). The hemodynamic consequences for both, the right and left ventricles, are significant. However, the right ventricle may be in a disastrous situation, since a compromised right ventricle from longstanding pressure overload may not tolerate acute volume overload. Here we report a 28-year-old African adult patient with TOF and acute severe aortic valve regurgitation due to bacterial endocarditis with preoperative low cardiac output syndrome. After aortotomy a large abscess cavity underneath the left and non-coronary sinus and a TOF typical perimembranous ventricular septal defect (VSD) were visible. Autologous glutaraldehyde-treated pericardium was used to reconstruct the aortic-mitral curtain. For repair of the TOF a vertical incision in the right ventricular outflow tract was performed and the infundibular septum was resected. The perimembranous VSD was closed with glutaraldehyde-fixed autologous pericardium, whereas the cranial part of the patch formed the aortic annulus. An aortic homograft was implanted as a full aortic root. The patient recovered early and uneventful. Adult TOF may be complicated by acute aortic valve endocarditis with emergent surgical intervention. Homograft aortic valve replacement is feasible in this setting.

Key Words: Tetralogy of Fallot; Congenital heart disease; Endocarditis; Grown-up congenital heart disease; Cardiac surgery; Aortic valve

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				C. M. Stanescu and K. Branidou A case of 75-year-old survivor of unrepaired tetralogy of Fallot and quadricuspid aortic valve Eur J Echocardiogr, January 1, 2008; 9(1): 167 - 170. [Abstract] [Full Text] [PDF]