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Interactive Cardiovascular and Thoracic Surgery 3:311-313(2004)
© 2004 European Association of Cardio-Thoracic Surgery

Best evidence topic - Cardiac general

Is clopidogrel beneficial following coronary bypass surgery?

Darbhamulla V. Nagarajan, Philip S. Lewis and Joel Dunning*

Department of Cardiology, Stepping Hill Hospital, Stockport, Manchester, UK

* Corresponding author. Address: Department of Cardiothoracic Surgery, Freeman Hospital, Freeman Road, Newcastle upon Tyne, UK. Tel.: +44-780-154-8122; fax: +44-161-276-8538
joeldunning{at}doctors.org.uk

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether clopidogrel is superior to aspirin in preventing adverse events post coronary arterial bypass grafting. Altogether 220 papers were found using the reported search, of which four presented the best evidence to answer the clinical question. The author, journal, date and country of publication, patient group studied, study type, relevant outcomes, results, and study weaknesses of these papers are tabulated. We conclude that if aspirin is not tolerated, clopidogrel is an acceptable alternative, but there is no strong evidence that clopidogrel is superior to aspirin postcoronary surgery.

Key Words: Evidence-based medicine; Thoracic surgery; Platelet aggregation inhibitors; Postoperative complications




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B. Kunadian, A. R. Thornley, T. N. Babu, and J. Dunning
Should high risk patients receive clopidogrel as well as aspirin post coronary arterial bypass grafting?
Interactive CardioVascular and Thoracic Surgery, December 1, 2006; 5(6): 755 - 760.
[Abstract] [Full Text] [PDF]


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