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Interactive Cardiovascular and Thoracic Surgery 3:52-56(2004)
© 2004 European Association of Cardio-Thoracic Surgery

Work in progress report - Thoracic general

Polyhematoporphyrin-mediated photodynamic therapy and decortication in palliation of malignant pleural mesothelioma: a clinical pilot study

Veronika Matzia, Alfred Maiera,*, Michael Woltscheb and Freyja Maria Smolle-Jüttnera

a Department of Surgery, Division of Thoracic and Hyperbaric Surgery, University Medical School, Auenbruggerplatz 29, A-8036 Graz, Austria
b Department of Pneumology, LKH Hörgas-Enzenbach, Austria

* Corresponding author. Tel.: +43-316-385-3302; fax: +43-316-385-4679
alf.maier{at}kfunigraz.ac.at

The aim of this study was to evaluate the additional effect of intraoperative photodynamic therapy (PDT) under hyperbaric oxygenation (HBO) when compared with decortication alone. From 1/1993 to 8/2002, palliation with decortication was done in 25 patients suffering from advanced malignant pleural mesothelioma. Fourteen patients received additional intraoperative PDT under HBO. The surgery and PDT/HBO was done 48 h after photosensitization with a polyhematoporphyrin, 2 mg/kg/BW using a diode laser delivering red light at 630 nm through a microlens. The light dose was calculated for 300 J with a distance of 1 cm from the tumor surface. At 6-month follow up local tumor control and survival showed a significant difference in both groups. Although the study only includes a small number of patients not allowing definite conclusions, it indicates that the additional PDT/HBO represents a safe and technically feasible approach in the palliative setting of advanced malignant mesothelioma of the pleura.

Key Words: Pleural mesothelioma; Photodynamic therapy

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