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Right arrow Lung - transplantation
Interactive Cardiovascular and Thoracic Surgery 2:509-513(2003)
© 2003 European Association of Cardio-Thoracic Surgery

Work in progress report - Experimental

Prevention of lung allograft rejection by combined treatment with adhesion molecule antibodies and cyclosporine

Michael Brandta,*, Christian Grotkopa, Jörg Steinmannb and Gustav Steinhoffa

a Department of Cardiovascular Surgery, University-Hospital, Arnold-Heller-Strasse 7, 24105 Kiel, Germany
b Institute of Immunology, University-Hospital, Arnold-Heller-Strasse 7, 24105 Kiel, Germany

* Corresponding author. Tel.: +49-431-597-4401; fax: +49-431-597-4402
mbrandt{at}kielheart.uni-kiel.de

Infiltration of leukocytes into the lung allograft is regulated by adhesion molecules during acute rejection. The purpose of this study was to assess the effect of monoclonal antibodies against ICAM-1 (1A29) to prevent rejection after lung transplantation. Left lateral orthotopic lung transplantation was performed using Dark Agouti rats as donors and Lewis rats as recipients. Recipients received 1A29 alone (group A), cyclosporine A alone (group B), a combination of both drugs (group C) or no therapy (group D). Animals were killed on day 5 and 10, respectively. Rejection was graded by histology. Myeloperoxidase activity (MPO) was measured in the graft. In allografts treated with cyclosporine and 1A29 histologically a lower grade of rejection was seen and less MPO were detected compared to groups A, B and D. Anti-ICAM-1 monoclonal antibodies alone as well as a subtherapeutic dose of cyclosporine are not effective to prevent acute allograft rejection after lung transplantation. However, the combination of both strategies significantly reduces rejection in this model.

Key Words: Adhesion molecule; Monoclonal antibody; Rat lung transplantation; Cyclosporine; Rejection

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