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Evaluation of cerebral pathologic changes and long-term behavioral disorder after deep hypothermic circulatory arrest in dogs

^a Department of General Surgery, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba 260-8677, Japan
^b Department of Cardiovascular Surgery, Chiba National Hospital, Chiba City, Chiba, Japan

^* Corresponding author. Tel.: +81-43-222-7171; fax: +81-43-222-5241
shimurah{at}ho.chiba-u.ac.jp

The purpose of this study is to evaluate the extent of brain damage following deep hypothermic circulatory arrest (DHCA), using behavior and pathological findings. The dogs underwent 60, 90 or 120 min of DHCA. After 72 h or 6 months, their cerebrum pathological findings were examined. No neurological deficit was found in any of the dogs. After 72 h, hippocampus cells (CA1) were TUNEL positive in 120-min-DHCA dogs. This study demonstrates that 90-min-DHCA-dogs can survive healthily over 6 months, and apoptotic cell death occurs in canine hippocampus following 120 min of DHCA at 15 °C.

Key Words: Hypothermia; Circulatory arrest; Apoptosis; Dog