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Right arrow Lung - cancer
Interactive Cardiovascular and Thoracic Surgery 2:201-205(2003)
© 2003 European Association of Cardio-Thoracic Surgery

Negative results - Thoracic general

Lack of prognostic significance of tumor angiogenesis in resected pN2 non-small cell lung cancer

Masaki Tomita*, Yasunori Matsuzaki, Masao Edagawa, Tetsuya Shimizu, Masaki Hara and Toshio Onitsuka

Department of Surgery II, Miyazaki Medical College, Kihara 5200, Kiyotake, Miyazaki 889-1692, Japan

* Corresponding author. Tel.: +81-985-85-2291; fax: +81-985-85-5563
mtomita{at}post.miyazaki-med.ac.jp

Objective: Despite extensive studies of tumor angiogenesis in non-small cell lung cancer, only a few studies had concentrated on pN2 disease. Methods: Sixty patients with pN2 non-small cell lung cancer who had undergone a complete resection with a systematic mediastinal lymph node dissection were reviewed retrospectively. Immunohistochemical study, using antibodies against factor VIII, was conducted. We compared between 5-year survivors and the others rather than the cumulative survival rate. Results: There were 13 patients (21.7%) survived longer than 5 years after a surgical resection. The microvessel density in survivor and non-survivor group was 22.9±14.8 and 24.3±21.9, respectively. This data indicated that microvessel density might not be related to the ratio of 5-year survivors (). Multivariate analysis also showed that microvessel density was not independent prognostic factor. Conclusions: We failed to find a prognostic significance of tumor angiogenesis in pN2 disease. Although tumor angiogenesis might be important for the development and maintenance, it was not identified as a prognostic factor of pN2 non-small cell lung cancer.

Key Words: pN2 disease; Tumor angiogenesis

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