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Mitsuya Murase
Yuichi Ueda
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Interactive Cardiovascular and Thoracic Surgery 1:88-92(2002)
© 2002 European Association of Cardio-Thoracic Surgery

Institutional review

pH-stat blood gas management provides better cerebral perfusion during deep hypothermic retrograde cerebral perfusion

Takao Nishizawa, Akihiko Usui*, Mitsuya Murase and Yuichi Ueda

Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-8550, Japan

* Corresponding author. Tel.: +81-52-744-2376; fax: +81-52-744-2383
ausui{at}med.nagoya-u.ac.jp

We performed a retrospective comparative clinical study to evaluate whether pH-stat () or alpha-stat strategy () provides better perfusion or oxygen metabolism during hypothermic retrograde cerebral perfusion (RCP). The pH-stat group showed significantly lower superior vena cava (SVC) pressure (21±4 versus 27±6 mmHg, ), apparently lower retrograde cerebral vascular resistance index (7.4±2.1 versus 10.1±3.8 dynes/s cm–5 m–2, ) but there were no significant differences in RCP flow index, oxygen supply or oxygen extraction between groups. Further studies are necessary to determine which blood gas management is better for RCP, however, pH-stat strategy should be useful in deep hypothermic RCP.

Key Words: Brain protection; Aortic surgery; Brain circulation; Brain metabolism; Acid base management




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M. Pokela, S. Dahlbacka, F. Biancari, V. Vainionpaa, T. Salomaki, K. Kiviluoma, E. Ronka, T. Kaakinen, J. Heikkinen, J. Hirvonen, et al.
pH-stat versus alpha-stat perfusion strategy during experimental hypothermic circulatory arrest: a microdialysis study
Ann. Thorac. Surg., October 1, 2003; 76(4): 1215 - 1226.
[Abstract] [Full Text] [PDF]


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