This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Xavier M. Mueller Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mueller, X. M. Articles by von Segesser, L. K. Search for Related Content PubMed PubMed Citation Articles by Mueller, X. M. Articles by von Segesser, L. K. Related Collections Congenital - cyanotic Extracorporeal circulation Mechanical Circulatory Assistance Minimally invasive surgery

Optimized venous return with a self-expanding cannula: from computational fluid dynamics to clinical application

Department of Cardio-Vascular Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon 46, CH-1011 Lausanne, Switzerland

^* Corresponding author. Tel.: +41-21-314-23-13; fax: +41-21-314-22-78
ludwig.von-segesser{at}chuv.hospvd.ch

The Smart canula^TM concept allows for collapsed cannula insertion, and self-expansion within a vein of the body. (A) Computational fluid dynamics, and (B) bovine experiments (76±3.8 kg) were performed for comparative analyses, prior to (C) the first clinical application. For an 18F access, a given flow of 4 l/min (A) resulted in a pressure drop of 49 mmHg for smart cannula versus 140 mmHg for control. The corresponding Reynolds numbers are 680 versus 1170, respectively. (B) For an access of 28F, the maximal flow for smart cannula was 5.8±0.5 l/min versus 4.0±0.1 l/min for standard (), for 24F 5.5±0.6 l/min versus 3.2±0.4 l/min (), and for 20F 4.1±0.3 l/min versus 1.6±0.3 l/min (). The flow obtained with the smart cannula was 270±45% (20F), 172±26% (24F), and 134±13% (28F) of standard (one-way ANOVA, ). (C) First clinical application (1.42 m²) with a smart cannula showed 3.55 l/min (100% predicted) without additional fluids. All three assessment steps confirm the superior performance of the smart cannula design.

Key Words: Cardiopulmonary bypass; Drainage; Cannula; Perfusion; Catheter

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